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Home / Primary Antibodies / Polyclonal Antibodies

ATF4 antibody

SKU : BHA10800657

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Mfr.No.	FNab00662
Alternative Names	CREB2 ; TXREB
Background	Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT(AC)(AG)-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Host	Rabbit
Immunogen	activating transcription factor 4(tax-responsive enhancer element B67)
Isotype	IgG
Molecular Weight	50-58 kDa, 35-38 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB

Uniprot	P18848
Gene Id	468
Research Area	Epigenetics, Developmental biology, Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP, FC
Description	ELISA ; WB ; IHC ; IP ; FC
Tested Application	WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

Manual	FNab00662.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800657	FNab00662	100ug	$240		Add to Cart

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