This protein binds the cAMP response element(CRE)(consensus: 5'-GTGACGT(AC)(AG)-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element(TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Categories
Primary Antibodies
Clonality
polyclonal
Description
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Host
Rabbit
Immunogen
activating transcription factor 1
Isotype
IgG
Molecular Weight
35 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ATF1, EWS ATF1, FUS/ATF 1, Protein TREB36, TREB36
Uniprot
P18846
Gene Id
466
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)