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Home / Primary Antibodies / Polyclonal Antibodies

Ataxin 2 antibody

SKU : BHA10800652

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Mfr.No.	FNab00657
Background	This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	ataxin 2
Isotype	IgG
Molecular Weight	140-150 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ataxin 2, ATX2, ATXN2, SCA2, TNRC13

Uniprot	Q99700
Gene Id	6311
Research Area	Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF, WB, IP
Description	ELISA ; IHC ; IF ; WB ; IP
Tested Application	WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab00657.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800652	FNab00657	100ug	$240		Add to Cart

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