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Home / Primary Antibodies / Polyclonal Antibodies

ASNA1 antibody

SKU : BHA10800638

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Mfr.No.	FNab00643
Alternative Names	ARSA ; TRC40
Background	This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.
Categories	Primary Antibodies
Clonality	polyclonal
Description	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Host	Rabbit
Immunogen	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Isotype	IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ARSA, TRC40

Uniprot	O43681
Gene Id	439
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, FC, IP
Description	ELISA ; WB ; IHC ; IF ; FC ; IP
Tested Application	WB: 1:200 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00643.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800638	FNab00643	100ug	$240		Add to Cart

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