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Home / Primary Antibodies / Polyclonal Antibodies

ASGR1 antibody

SKU : BHA10800630

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Mfr.No.	FNab00635
Alternative Names	CLEC4H1
Background	This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Host	Rabbit
Immunogen	asialoglycoprotein receptor 1
Isotype	IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ASGP R 1, ASGPR, ASGPR 1, Asgpr1, ASGR1, asialoglycoprotein receptor 1, CLEC4H1, Hepatic lectin H1, HL 1, Hs.12056

Uniprot	P07306
Gene Id	432
Research Area	Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:1000 - 1:4000; IHC: 1:50 - 1:200

Manual	FNab00635.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800630	FNab00635	100ug	$240		Add to Cart

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