The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants.
Clonality
polyclonal
Host
Rabbit
Immunogen
ADP-ribosylation factor GTPase activating protein 1
Immunogen Region
ADP-ribosylation factor GTPase actIVating protein 1
Isotype
IgG
Molecular Weight
45 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
Synonyms
ARF GAP 1, ARF1 GAP, ARF1GAP, ARFGAP1, HRIHFB2281
Uniprot
Q8N6T3
Gene Id
55738
Research Area
Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10028.pdf" target="_blank">Data Sheet</ a>