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Home / Primary Antibodies / Polyclonal Antibodies

APC antibody

SKU : BHA10800468

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Mfr.No.	FNab00473
Alternative Names	DP2.5
Background	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor(HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Host	Rabbit
Immunogen	adenomatous polyposis coli
Isotype	IgG
Molecular Weight	300 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC

Uniprot	P25054
Gene Id	324
Research Area	Cell Division and Proliferation, Cancer, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC
Description	ELISA ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:20-1:200

Manual	FNab00473.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800468	FNab00473	100ug	$240		Add to Cart

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