Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA(CG)TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer(CRC) cells(PubMed:24623306). Binds to the USP28 promoter in colorectal cancer(CRC) cells(PubMed:24623306).
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
jun oncogene
Isotype
IgG
Molecular Weight
44 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
Activator protein 1, AP 1, AP1, c Jun, JUN, jun oncogene, P39, Proto oncogene c Jun, Transcription factor AP 1
Uniprot
P05412
Gene Id
3725
Research Area
Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)