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Home / Antibodies

Anti-Yeast ULP1 Antibody

SKU : BHA10918885

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y050057
Categories	Primary Antibodies
Clonality	polyclonal
Description	ULP-1, ubiquitin-like protein-specific protease 1, initially processes Smt3 and also acts as adeconjugating enzyme for Smt3 [Saccharomyces cerevisiae (Baker's yeast)]. Covalent modification of cellular proteins by theubiquitin-like modifier SUMO (small ubiquitin-like modifier) regulates various cellular processes, such as nuclear transport, signaltransduction, stress responses and cell cycle progression. But, in contrast to ubiquination, sumoylation does not tag proteins fordegradation by the 26S proteasome, but rather seems to enhance stability or modulate their subcellular compartmentalization. Oncecovalently attached to cellular targets, SUMO regulates protein:protein and protein:DNA interactions, as well as localization andstability of the target protein. Sumoylation occurs in most eukaryotic systems, and SUMO is highly conserved from yeast to humans.Where invertebrates have only a single SUMO gene termed SMT3, three members of the SUMO family have been identified invertebrates: SUMO-1 and the close homologues SUMO-2 and SUMO-3. Three distinct steps can be distinguished in the SUMOmodification pathway: 1) activation of SUMO, 2) transfer of SUMO to the conjugating enzyme, and 3) substrate modification. SinceSUMO is synthesized as a precursor protein, a maturation step precedes the activation reaction. In yeast, C-terminal processing of theSUMO precursor is mediated by the processing protease Ulp1, which has an additional role in the deconjugation of SUMO-modifiedsubstrates. Mature SUMO is activated by SUMO-activating enzyme, an E1-like heterodimeric protein complex composed of Uba2 andAos1. Ulp1 function has provided evidence that SUMO modification in yeast, as has been suspected for vertebrates, plays animportant role in nucleocytoplasmic trafficking.
Formulation	Liquid
Host	Rabbit(Rb)
Guarantee	abm guarantees that all our Anti-Yeast ULP1 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	This purified antibody was prepared from rabbit serum after repeated immunizations with recombinant yeast ULP-1protein.
Isotype	IgG
Quantity	100 μg
Recommended Dilution	This purified polyclonal antibody reacts with yeast ULP-1 by western blot and ELISA. Although not tested, thisantibody is likely functional in immunohistochemistry and immunoprecipitation. Specific conditions for reactivity should be optimizedby the end user. Expect a band approximately 72.4 kDa in size corresponding to yeast ULP-1 by western blotting in the appropriatelysate or extract.
Shipping Condition	Ice Packs
Specificity	This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process whichincludes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer statedabove. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. Reactivity against ULP-1 fromother sources or ULP-2 has not been determined.

Gene Name	Yeast ULP1
Clone No	Polyclonal

Concentration	1µg/ul
Purity	Affinity Purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	ELISA ; WB

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10918885	Y050057	100 ug	$1162.50		Add to Cart

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