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Home / Primary Antibodies / IHC Antibodies

Anti-TNFRSF11B Antibody BHA11300967

SKU : BHA11300967

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Mfr.No.	BS1862
Alternative Names	Tumor necrosis factor receptor superfamily member 11B ; Osteoclastogenesis inhibitory factor ; Osteoprotegerin ; TNFRSF11B ; OCIF ; OPG
Categories	Primary Antibodies
Chromosome Location	8q24.12
Clonality	polyclonal
Description	The cytokine osteoprotegerin(OPG), also designated osteoclastogenesis inhibitory factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 1-50 of Human OPG.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O00300
Uniprot	O00300
Weight	46 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: OPG (P25) polyclonal antibody detects endogenous levels of Osteoprotegerin protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300967	BS1862	50µl	$190.44		Add to Cart
BHA11300967	BS1862	100µl	$294.44		Add to Cart

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