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Home / Primary Antibodies / IHC Antibodies

Anti-PTPN11 Antibody BHA11302454

SKU : BHA11302454

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Mfr.No.	BS4170
Alternative Names	Tyrosine-protein phosphatase non-receptor type 11 ; Protein-tyrosine phosphatase 1D ; PTP-1D ; Protein-tyrosine phosphatase 2C ; PTP-2C ; SH-PTP2 ; SHP-2 ; Shp2 ; SH-PTP3 ; PTPN11 ; PTP2C ; SHPTP2
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	12q24.13
Clonality	polyclonal
Description	Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 542.
Modification	phospho-Y542
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q06124
Uniprot	Q06124
Weight	70 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-SHP-2 (Y542) polyclonal antibody detects endogenous levels of SHP-2 protein only when phosphorylated at Tyr542.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302454	BS4170	50µl	$199.33		Add to Cart
BHA11302454	BS4170	100µl	$314.89		Add to Cart

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