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Home / Primary Antibodies / Phospho Antibodies

Anti-PDGFRB Antibody BHA11304717

SKU : BHA11304717

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Mfr.No.	BS64002
Alternative Names	Platelet-derived growth factor receptor beta ; PDGF-R-beta ; PDGFR-beta ; EC=2.7.10.1 ; Beta platelet-derived growth factor receptor Beta-type platelet-derived growth factor receptor CD140 antigen-like family member B ; Platelet-derived growth factor receptor 1 ; PDGFR-1 ; CD140b ; PDGFRB ; PDGFR, PDGFR1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	5q32
Clonality	polyclonal
Description	PDGF is amitogen formesenchyme- and glia-derived cells. Itconsists of two disulfide-bonded polypeptide chains, A and B, and occurs asthree isoforms, PDGF-AA, PDGF-AB and PDGF-BB. The three isoforms bindwith different affinitiesto two receptor types, A and B,which are structurallyrelated and possess protein-tyrosine kinase domains.Ligand binding induces activation of the receptorkinases byformation of receptor dimers; the A subunit of PDGF binds onlyto A receptorswith high affinity,whereasthe B subunitcan bind to both A and B receptors. Evidence suggeststhat PDGFmayfunction as a neurotrophicfactor. The fact that PDGFtype A receptors are expressed in oligodendrocyte progenitorcellswhereas PDGFtype B receptors are expressed on neuronssuggeststhat the different isoforms of PDGF may regulate growth and differentiation of differentcell typesin the developing central nervoussystemby paracrine and autocrine routes
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human PDGFR-β around the phosphorylation site of Tyrosine 1009.
Modification	phospho-Y1009
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P09619
Uniprot	P09619
Weight	190 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-PDGFR-β (Y1009) polyclonal antibody detects endogenous levels of PDGFR-β protein only when phosphorylated at Tyr1009.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304717	BS64002	50µl	$199.33		Add to Cart
BHA11304717	BS64002	100µl	$314.89		Add to Cart

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