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Home / Primary Antibodies / Recombinant Antibodies

Anti-PDCD4 Antibody BHA11306721

SKU : BHA11306721

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Mfr.No.	BS7192
Alternative Names	Programmed cell death protein 4 ; Neoplastic transformation inhibitor protein ; Nuclear antigen H731-like ; Protein 197/15a ; PDCD4 ; H731
Categories	Primary Antibodies
Clonality	polyclonal
Description	The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun.
Host	Rabbit
Immunogen	Recombinant full length Human PDCD4.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO

Swissprot	Q53EL6
Uniprot	Q53EL6
Weight	51 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: PDCD4 polyclonal antibody detects endogenous levels of PDCD4 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IP, FC

Description

WB ; IHC ; IP ; FC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100
IP	1:20-1:50
FC1	20-1:50

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11306721	BS7192	50µl	$234.89		Add to Cart
BHA11306721	BS7192	100µl	$368.22		Add to Cart

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