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Home / Primary Antibodies / IHC Antibodies

Anti-NR3C1 Antibody BHA11302373

SKU : BHA11302373

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Mfr.No.	BS4081
Alternative Names	Glucocorticoid receptor ; GR ; Nuclear receptor subfamily 3 group C member 1 ; NR3C1 ; GRL
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	5q31.3
Clonality	polyclonal
Description	The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human GR around the phosphorylation site of Serine 226.
Modification	phospho-S226
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P04150
Uniprot	P04150
Weight	90 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-GR (S226) polyclonal antibody detects endogenous levels of GR protein only when phosphorylated at Ser226
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302373	BS4081	50µl	$199.33		Add to Cart
BHA11302373	BS4081	100µl	$314.89		Add to Cart

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