Integral membrane protein. Found in late endosomes and lysosomes.
Clonality
polyclonal
Description
Rabbit polyclonal to NPC1L1
Host
Rabbit
Immunogen
Synthetic peptide: FLEEMRAFQRRMAGM, corresponding to amino acids 596-610 of Human NPC1L1(Niemann Pick C1 Like 1).
Isotype
IgG
Quantity
100 µl
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Concentration
1µg/ul
Description
Specificity: This Polyclonal antibody is directed against human NPC1L1 protein. The product was purified from seurm by protein A chromatography. Expect reactivity with human NPC1L1. Cross-reactivity with NPC1L1 from other sources has not been determined.Relevance: NPC1L1 encodes a deduced 1359 amino acid protein. Two alternatively spliced transcripts encode truncated proteins, one with 724 amino acids (NPC1L1T) and the other with a 27 amino acid in frame deletion (NPC1L1delE15). NPC1L1 is involved in lipid transport and the intracellular trafficking of cholesterol. NPC1L1 also has a role in diet induced hypercholesterolemia, and may play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
Format
Liquid
Purity
Affinity purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB
Description
Recommended dilutionsWB: 1/2000.Predicted molecular weight: 145 kDa.Not yet tested in other applications.Optimal dilutions/concentrations should be determined by the end user., WB