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Home / Antibodies

Anti-MRC1 Antibody BHA11302890

SKU : BHA11302890

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Mfr.No.	BS5654
Alternative Names	Macrophage mannose receptor 1 ; MMR ; C-type lectin domain family 13 member D ; C-type lectin domain family 13 member D-like ; Macrophage mannose receptor 1-like protein 1 ; CD206 ; MRC1 ; CLEC13D ; CLEC13DL ; MRC1L1
Categories	Primary Antibodies
Chromosome Location	10p12.33
Clonality	polyclonal
Description	CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 685-730 of Human CD206.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P22897
Uniprot	P22897
Weight	166 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: CD206 polyclonal antibody detects endogenous levels of CD206 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, ICC

Description

WB ; ICC

Dilution

WB	1:500-1:1000
ICC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302890	BS5654	50µl	$190.44		Add to Cart
BHA11302890	BS5654	100µl	$294.44		Add to Cart

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