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Home / Primary Antibodies / IHC Antibodies

Anti-HDAC8 Antibody BHA11308331

SKU : BHA11308331

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Mfr.No.	BS8499
Alternative Names	Histone deacetylase 8 ; HD8 ; HDAC8 ; HDACL1 ; CDA07
Categories	Primary Antibodies
Chromosome Location	Xq13.1
Clonality	polyclonal
Description	In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
Host	Rabbit
Immunogen	Recombinant full length Human HDAC8.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9BY41
Uniprot	Q9BY41
Weight	41kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: HDAC8 polyclonal antibody detects endogenous levels of HDAC8 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308331	BS8499	50µl	$234.89		Add to Cart
BHA11308331	BS8499	100µl	$368.22		Add to Cart

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