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Home / Primary Antibodies / IHC Antibodies

Anti-GRK1 Antibody BHA11301841

SKU : BHA11301841

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Mfr.No.	BS3251
Alternative Names	Rhodopsin kinase ; RK ; G protein-coupled receptor kinase 1 ; RHOK
Categories	Primary Antibodies
Chromosome Location	13q34
Clonality	polyclonal
Description	Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminal of Human GRK1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q15835
Uniprot	Q15835
Weight	63 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: GRK1 (A17) polyclonal antibody detects endogenous levels of GRK1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301841	BS3251	50µl	$190.44		Add to Cart
BHA11301841	BS3251	100µl	$294.44		Add to Cart

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