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Home / Primary Antibodies / Phospho Antibodies

Anti-ESR1 Antibody BHA11302632

SKU : BHA11302632

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Mfr.No.	BS4683
Alternative Names	Estrogen receptor ; ER-alpha ; ER ; ESR1 ; ESR ; NR3A1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	6q25.1-q25.2
Clonality	polyclonal
Description	Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus , though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human ERα around the phosphorylation site of Tyrosine 537.
Modification	phospho-Y537
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P03372
Uniprot	P03372
Weight	66 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-ERα (Y537) polyclonal antibody detects endogenous levels of ERα protein only when phosphorylated at Tyr537.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302632	BS4683	50µl	$199.33		Add to Cart
BHA11302632	BS4683	100µl	$314.89		Add to Cart

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