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Home / Primary Antibodies / IHC Antibodies

Anti-ERBB2 Antibody BHA11302381

SKU : BHA11302381

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Mfr.No.	BS4090
Alternative Names	Receptor tyrosine-protein kinase erbB-2 ; Metastatic lymph node gene 19 protein ; MLN 19 ; Proto-oncogene Neu ; Proto-oncogene c-ErbB-2 ; Tyrosine kinase-type cell surface receptor HER2 ; p185erbB2 ; CD340 ; ERBB2 ; HER2 ; MLN19 ; NEU ; NGL
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	17q12
Clonality	polyclonal
Description	The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human ErbB2/HER2 around the phosphorylation site of Tyrosine 1248.
Modification	phospho-Y1248
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P04626
Uniprot	P04626
Weight	138,185 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-ErbB2/HER2 (Y1248) polyclonal antibody detects endogenous levels of ErbB2/HER2 protein only when phosphorylated at Tyr1248.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302381	BS4090	50µl	$199.33		Add to Cart
BHA11302381	BS4090	100µl	$314.89		Add to Cart

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