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Home / Primary Antibodies / IHC Antibodies

Anti-EIF2AK2 Antibody BHA11302710

SKU : BHA11302710

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Mfr.No.	BS4788
Alternative Names	Interferon-induced ; double-stranded RNA-activated protein kinase ; Eukaryotic translation initiation factor 2-alpha kinase 2 ; eIF-2A protein kinase 2 ; Interferon-inducible RNA-dependent protein kinase ; P1/eIF-2A protein kinase ; Protein kinase RNA-activated ; PKR ; Tyrosine-protein kinase EIF2AK2 ; p68 kinase ; PKR ; PRKR ; EIF2AK2
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	2p22.2
Clonality	polyclonal
Description	An interferon-inducible, RNA-dependent protein serine/threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the α subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2α on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human PKR around the phosphorylation site of Threonine 451.
Modification	phospho-T451
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P19525
Uniprot	P19525
Weight	Predicted band size : 62 kDaObserved band size : 68 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-PKR (T451) polyclonal antibody detects endogenous levels of PKR protein only when phosphorylated at Thr451.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302710	BS4788	50µl	$199.33		Add to Cart
BHA11302710	BS4788	100µl	$314.89		Add to Cart

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