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Home / Primary Antibodies / IHC Antibodies

Anti-DUSP1 Antibody BHA11300825

SKU : BHA11300825

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Mfr.No.	BS1677
Alternative Names	Dual specificity protein phosphatase 1 ; Dual specificity protein phosphatase hVH1 ; Mitogen-activated protein kinase phosphatase 1 ; MAP kinase phosphatase 1 ; MKP-1 ; Protein-tyrosine phosphatase CL100 ; DUSP1 ; CL100 ; MKP1 ; PTPN10 ; VH1
Categories	Primary Antibodies
Chromosome Location	5q35.1
Clonality	polyclonal
Description	The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 325-370 of Human MKP1.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P28562
Uniprot	P28562
Weight	39 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: MKP1 (S355) polyclonal antibody detects endogenous levels of MKP1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300825	BS1677	50µl	$190.44		Add to Cart
BHA11300825	BS1677	100µl	$294.44		Add to Cart

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