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Home / Primary Antibodies / IHC Antibodies

Anti-ATF1 Antibody BHA11302156

SKU : BHA11302156

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Mfr.No.	BS3717
Alternative Names	Cyclic AMP-dependent transcription factor ATF-1 ; cAMP-dependent transcription factor ATF-1 ; Activating transcription factor 1Protein TREB36 ; ATF1
Categories	Primary Antibodies
Chromosome Location	12q13.12
Clonality	polyclonal
Description	Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/ CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-1 is shown to play a key role in the induction of NOX1, this protein binds the cAMP response element (CRE) and mediates PKA-induced stimulation of CRE-reporter genes. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CREdependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 functions as a histone acetyltransferase (HAT) and acetylates Histones H2B and H4 specifically in vitro.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 20-70 of Human ATF1.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P18846
Uniprot	P18846
Weight	29, 36 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: ATF1 (I57) polyclonal antibody detects endogenous levels of ATF1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302156	BS3717	50µl	$190.44		Add to Cart
BHA11302156	BS3717	100µl	$294.44		Add to Cart

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