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Home / Primary Antibodies / Phospho Antibodies

Anti-ARRB1 Antibody BHA11300032

SKU : BHA11300032

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Mfr.No.	AP0240
Alternative Names	ARB 1 ; ARB1 ; ARR 1 ; ARR1 ; ARRB 1 ; ARRB1 ; Arrestin 2 ; Arrestin beta 1 ; Arrestin beta-1 ; Beta-arrestin-1 ; Arrestin-β1 ; Arrestin β1 ; β-arrestin-1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	11q13.4
Clonality	polyclonal
Description	Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human Arrestin-β-1 around the phosphorylation site of Serine 412.
Modification	phospho-S412
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P49407
Uniprot	P49407
Weight	50 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: p-Arrestin-β-1 (S412) polyclonal antibody detects endogenous levels of Arrestin-β-1 protein only when phosphorylated at Ser412.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300032	AP0240	50µl	$199.33		Add to Cart
BHA11300032	AP0240	100µl	$314.89		Add to Cart

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