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Home / Primary Antibodies / Phospho Antibodies

Anti-ABL1 Antibody BHA11302775

SKU : BHA11302775

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Mfr.No.	BS5002
Alternative Names	Tyrosine-protein kinase ABL1 ; Abelson murine leukemia viral oncogene homolog 1 ; Abelson tyrosine-protein kinase 1 ; Proto-oncogene c-Abl ; p150 ; ABL1 ; ABL ; JTK7
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	9q34.12
Clonality	polyclonal
Description	The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human ABL1 around the phosphorylation site of Tyrosine 412.
Modification	phospho-Y412
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P00519
Uniprot	P00519
Weight	123 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-ABL1 (Y412) polyclonal antibody detects endogenous levels of ABL1 protein when phosphorylated at Tyr412.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302775	BS5002	50µl	$199.33		Add to Cart
BHA11302775	BS5002	100µl	$314.89		Add to Cart

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