Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Categories
Primary Antibodies
Cellular Localization
Endosome, Membrane
Clonality
polyclonal
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Host
Rabbit
Immunogen
ankyrin repeat domain 13 family, member D
Isotype
IgG
Molecular Weight
58 kDa
Reactivity
Human
Regulatory
RUO
Subcellular Location
Cell membrane, Endosome, Membrane
Uniprot
Q6ZTN6
Gene Id
338692
Research Area
Signal Transduction
Weight
58kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)