ANKRD11, also named as ANCO1, may recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. This antibody is specific to ANKRD11. ANKRD11 exists 150-170 kDa isoform.
Categories
Primary Antibodies
Cellular Localization
Nucleus
Clonality
polyclonal
Description
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).