This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Categories
Primary Antibodies
Cellular Localization
Secreted
Clonality
polyclonal
Host
Rabbit
Immunogen
angiopoietin 1
Isotype
IgG
Molecular Weight
53 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Secreted
Synonyms
AGP1, AGPT, ANG 1, ANG1, angiopoietin 1, ANGPT1, KIAA0003
Uniprot
Q15389
Gene Id
284
Research Area
Developmental biology, Immunology, Cardiovascular, Signal Transduction
Weight
58kDa,observed 70kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)