This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1, 4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas.
Categories
Primary Antibodies
Cellular Localization
Secreted
Clonality
polyclonal
Description
The complete human amylase gene contains five intact genes: two pancreatic genes (AMY2A and AMY2B) and three salivary genes (AMYIA, AMYIB, and AMYIC). AMY2A(Pancreatic alpha-amylase)is also named as PA and is a 56 kDa protein consisting of 496 amino acids in a single polypeptide chain, folded into three domains(PMID:10657258).AMY2A and AMY2B transcripts are present in the human pancreas but not in the parotid salivary gland, while AMY1 transcripts are present in the parotid gland but not in the pancreas(PMID:1692956). 15845-1-AP can recognize both AMY1 and AMY2.
Host
Rabbit
Immunogen
amylase, alpha 2A (pancreatic)
Isotype
IgG
Molecular Weight
58 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Secreted
Synonyms
AMY2A, Amylase, alpha, Pancreatic alpha amylase
Uniprot
P04746
Gene Id
279
Research Area
Metabolism
Weight
58kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)