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Home / Primary Antibodies / Polyclonal Antibodies

Amphiregulin antibody

SKU : BHA10800369

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Mfr.No.	FNab00374
Alternative Names	Amphiregulin ; AR ; AREG ; AREGB ; CRDGF ; SDGF
Background	Amphiregulin(AREG) is one of the ligands of the epidermal growth factor receptor(EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms(PMID: 9642297).
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms (PMID: 9642297).
Host	Rabbit
Immunogen	amphiregulin
Isotype	IgG
Molecular Weight	43 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Membrane
Synonyms	Amphiregulin, AR, AREG, AREGB, CRDGF, SDGF

Uniprot	P15514
Gene Id	374
Research Area	Immunology, Cardiovascular, Signal Transduction
Weight	28kDa,observed 43kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IF, WB, IHC, FC, IP

Description

ELISA ; IF ; WB ; IHC ; FC ; IP

Dilution

WB	1:200-1:2000
IHC	1:50-1:500
IP	1:1000-1:10000
IF	1:10-1:100

Tested Application

WB: 1:200-1:2000; IHC: 1:50-1:500; IP: 1:1000-1:10000; IF: 1:10-1:100

Manual	FNab00374.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800369	FNab00374	100ug	$240		Add to Cart

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