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Home / Primary Antibodies / Polyclonal Antibodies

Amphiphysin antibody

SKU : BHA10800368

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Mfr.No.	FNab00373
Alternative Names	Amphiphysin ; AMPH1 ; AMPH
Background	Amphiphysin(AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR(Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types.
Categories	Primary Antibodies
Cellular Localization	Cell Junction, Cytoplasm, Cytoplasmic Vesicle, cytoskeleton, Membrane, Synapse
Clonality	polyclonal
Description	Amphiphysin (AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR (Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. (PMID: 8552632; 8245793; 10559861)
Host	Rabbit
Immunogen	amphiphysin
Isotype	IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Synapse
Synonyms	Amphiphysin,AMPH1,AMPH

Uniprot	P49418
Research Area	Neuroscience
Weight	76kDa,observed 120kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IP	1:500-1:5000

Tested Application

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000

Manual	FNab00373.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800368	FNab00373	100ug	$240		Add to Cart

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