Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Categories
Primary Antibodies
Cellular Localization
Cell Junction, Tight Junction
Clonality
monoclonal
Description
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Host
Mouse
Immunogen
angiomotin
Isotype
IgG2b
Molecular Weight
130 kDa
Reactivity
Human
Regulatory
RUO
Subcellular Location
Cell junction, Tight junction
Synonyms
AMOT, angiomotin, KIAA1071
Uniprot
Q4VCS5
Gene Id
154796
Clone No
2C9
Research Area
Developmental biology, Cardiovascular
Weight
118kDa
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)