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Home / Primary Antibodies / Polyclonal Antibodies

AMBRA1 antibody

SKU : BHA10800352

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Mfr.No.	FNab00356
Alternative Names	AMBRA1 ; autophagy/beclin1regulator1 ; FLJ20294 ; KIAA1736 ; WDR94
Background	WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1, 298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic Vesicle
Clonality	polyclonal
Description	Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
Host	Rabbit
Immunogen	autophagy/beclin-1 regulator 1
Isotype	IgG
Molecular Weight	140 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasmic vesicle
Synonyms	AMBRA1, autophagy/beclin 1 regulator 1, FLJ20294, KIAA1736, WDR94

Uniprot	Q9C0C7
Gene Id	55626
Research Area	Developmental biology, Cardiovascular, Neuroscience
Weight	113kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF

Description

ELISA ; IHC ; WB ; IF

Dilution

WB	1:200-1:1000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00356.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800352	FNab00356	100ug	$240		Add to Cart

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