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Home / Primary Antibodies / Polyclonal Antibodies

AMACR/p504S antibody

SKU : BHA10800351

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Mfr.No.	FNab00355
Alternative Names	2methylacylCoAracemase ; alphamethylacylCoAracemase ; AMACR ; CBAS4 ; p504S ; RACE
Background	AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Categories	Primary Antibodies
Cellular Localization	Mitochondria, Peroxisome
Clonality	polyclonal
Description	AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
Host	Rabbit
Immunogen	alpha-methylacyl-CoA racemase
Isotype	IgG
Molecular Weight	42 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Mitochondrion, Peroxisome
Synonyms	2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE

Uniprot	Q9UHK6
Research Area	Stem Cells, Immunology, Metabolism, Cancer
Weight	42kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB

Description

ELISA ; IHC ; WB

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800351	FNab00355	100ug	$240		Add to Cart

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