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Home / Primary Antibodies

AMACR / p504S Antibody (Prostate Cancer Marker) (V8877)

SKU : BHA17119416

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NSJ Bioreagents

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Mfr.No.	V8877, V8877-20UG, V8877-100UG
Clonality	Polyclonal (rabbit origin)
Description	AMACR, also known as p504S, is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Rabbit
Immunogen Region	A synthetic peptide from human AMACR protein was used as the immunogen for the AMACR antibody.
Isotype	Rabbit IgG
Species Reactivity	Human
Note	Optimal dilution of the AMACR antibody should be determined by the researcher.

Uniprot	Q9UHK6

Format	Purified
Purity	Protein A affinity
Storage	Aliquot the AMACR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC-P
Description	Weste blot: 1:50-1:100,Immunohistochemistry (FFPE): 1:50-1:100

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17119416-1	V8877-20UG	20ug	$219		Add to Cart
BHA17119416-2	V8877-100UG	100ug	$499		Add to Cart

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