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Home / Primary Antibodies / Polyclonal Antibodies

ALPL antibody

SKU : BHA10800343

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Mfr.No.	FNab00347
Alternative Names	Alkalinephosphatase ; Alkalinephosphataseliver/bone/kidneyisozyme ; Alkalinephosphatasetissuenonspecificisozyme ; ALPL ; BLAP ; BoneAlkalinePhosphatase ; NBAP
Background	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney(tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL(Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa(PMID:18724009). ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H(Endo H)-sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol(GPI)(PMID:10839996).This antibody can bind the four mentioned alkaline phosphatases.
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	This isozyme may play a role in skeletal mineralization.
Host	Rabbit
Immunogen	alkaline phosphatase, liver/bone/kidney
Isotype	IgG
Molecular Weight	60-80 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Membrane
Synonyms	Alkaline phosphatase, Alkaline phosphatase liver/bone/kidney isozyme, Alkaline phosphatase tissue nonspecific isozyme, ALPL, BLAP, Bone Alkaline Phosphatase, NBAP

Uniprot	P05186
Gene Id	249
Research Area	Cell Division and Proliferation, Developmental biology, Stem Cells, Metabolism
Weight	57kDa,observed 80kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, FC

Description

ELISA ; WB ; IHC ; FC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:3000; IHC: 1:20-1:200

Manual	FNab00347.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800343	FNab00347	100ug	$240		Add to Cart

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