The protein encoded by ACTA2 (actin, alpha 2, smooth muscle, aorta) belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Clonality
Monoclonal
Description
Mouse Anti-alpha-SMA Monoclonal Antibody
Formulation
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, Liquid solution
Host
Mouse
Immunogen
Synthetic Peptide
Immunogen Region
Synthetic Peptide
Isotype
Mouse IgG1
Molecular Weight
42 KD
Others
The antibody detects endogenous alpha-SMA protein.
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity
Human, Mouse, Rat
Tag
Actin, aortic smooth muscle
Note
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:10000-1:100000), IF (1:100-1:200), IHC-P (1:1000-1:2000).
Accession Number
P62736
Gene Id
59, 59
Concentration
1 mg/ml, 1 mg/ml
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen
Storage Buffer
PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage Instructions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.