GLA, also named as Melibiase, Agalsidase and Alpha-galactosidase A, belongs to the glycosyl hydrolase 27 family. It hydrolyzes terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. Fabry disease is an X-linked lysosomal storage disorder resulting from the deficient activity of GLA. Enzyme replacement therapy(ERT) with GLA is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease.
Categories
Primary Antibodies
Cellular Localization
Lysosome Membrane
Clonality
monoclonal
Description
GLA, also named as Melibiase, Agalsidas and Alpha-galactosidase A, Belongs to the glycosyl hydrolase 28 family. It hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannan?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????Η???Ρ???????δ???ξ???χ???????????????????????Ё???????Е???П???Ш???в???м???х???я?????????????????????????????????????????????????????????????????????????????
Host
Mouse
Immunogen
galactosidase, alpha
Isotype
IgG2a
Molecular Weight
49 kDa
Reactivity
Human
Regulatory
RUO
Subcellular Location
Lysosome
Synonyms
Alpha galactosidase A, galactosidase, alpha
Uniprot
P06280
Gene Id
2717
Clone No
7F1
Research Area
Cardiovascular, Metabolism, Signal Transduction
Weight
49kDa
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)