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Home / Primary Antibodies / Polyclonal Antibodies

Alpha B Crystallin antibody

SKU : BHA10800322

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Mfr.No.	FNab00325
Alternative Names	AlphaBCrystallin ; AlphacrystallinBchain ; Alpha(B)crystallin ; CRYA2 ; CRYAB ; crystallin ; alphaB ; CTPP2 ; Heatshockproteinbeta5 ; HSPB5 ; Rosenthalfibercomponent
Background	Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms(SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Host	Rabbit
Immunogen	crystallin, alpha B
Isotype	IgG
Molecular Weight	20 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	Alpha B Crystallin, Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component

Uniprot	P02511
Research Area	Cancer, Metabolism, Neuroscience
Weight	20kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IP	1:200-1:2000

Tested Application

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800322	FNab00325	100ug	$240		Add to Cart

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