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Home / Primary Antibodies / Polyclonal Antibodies

alpha Adaptin antibody

SKU : BHA10800320

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Mfr.No.	FNab00323
Alternative Names	ADTAA ; alphaAdaptin ; AlphaadaptinA ; Alpha1adaptin ; AP2complexsubunitalpha1 ; AP2ALPHA ; AP2A1 ; CLAPA1
Background	This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
Categories	Primary Antibodies
Cellular Localization	Coated Pit, Membrane
Clonality	polyclonal
Description	AP2A1 encodes adaptor protein complex 2 (AP-2) subunit alpha-1, which is a 100 kDa coated vesicle protein. Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. AP-2 is involved in clathrin-dependent endocytosis.
Host	Rabbit
Immunogen	adaptor-related protein complex 2, alpha 1 subunit
Isotype	IgG
Molecular Weight	108 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Coated pit, Membrane
Synonyms	ADTAA, alpha Adaptin, Alpha adaptin A, Alpha1 adaptin, AP 2 complex subunit alpha 1, AP2 ALPHA, AP2A1, CLAPA1

Uniprot	O95782
Gene Id	160
Research Area	Developmental biology, Metabolism
Weight	108kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP, IF

Description

ELISA ; WB ; IHC ; IP ; IF

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00323.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800320	FNab00323	100ug	$240		Add to Cart

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