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Home / Primary Antibodies / Polyclonal Antibodies

Alpha-2-macroglobulin antibody

SKU : BHA10800336

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Mfr.No.	FNab00340
Alternative Names	A2M ; Alpha2M ; alpha2macroglobulin ; CPAMD5 ; DKFZp779B086 ; FWP007 ; S8637 ; α-2M
Background	Alpha-2-macroglobulin, also known as alpha2-macroglobulin(alpha2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer s disease.
Categories	Primary Antibodies
Cellular Localization	Secreted
Clonality	polyclonal
Description	Alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.
Host	Rabbit
Immunogen	alpha-2-macroglobulin
Isotype	IgG
Molecular Weight	185 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Secreted
Synonyms	A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, DKFZp779B086, FWP007, S863 7, alpha-2M

Uniprot	P01023
Gene Id	2
Research Area	Immunology, Cardiovascular, Metabolism, Signal Transduction
Weight	163kDa,observed 185kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:2000-1:20000
IP	1:200-1:1000
IF	1:50-1:500
IHC	1:20-1:200

Tested Application

WB: 1:2000-1:20000; IP: 1:200-1:1000; IF: 1:50-1:500; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800336	FNab00340	100ug	$240		Add to Cart

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