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Home / Primary Antibodies / Monoclonal Antibodies

Alpha-1-Antitrypsin antibody

SKU : BHA10800334

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Mfr.No.	FNab00338
Alternative Names	A1A ; A1AT ; AAT ; Alpha1antiproteinase ; Alpha1antitrypsin ; Alpha1proteaseinhibitor ; PI ; PI1 ; PRO2209 ; PRO2275 ; SerpinA1
Background	SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
Categories	Primary Antibodies
Cellular Localization	endoplasmic reticulum, Extracellular matrix, Secreted
Clonality	monoclonal
Description	SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
Host	Mouse
Immunogen	serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1
Isotype	IgG1
Molecular Weight	50 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Endoplasmic reticulum, Extracellular matrix, Secreted
Synonyms	A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, alpha1-antitrypsin

Uniprot	P01009
Gene Id	5265
Clone No	5B1
Research Area	Cancer, Immunology, Cardiovascular, Metabolism
Weight	50kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IF	1:20-1:200
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000

Manual	FNab00338.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800334	FNab00338	100ug	$300		Add to Cart

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