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Home / Primary Antibodies / Polyclonal Antibodies

alpha 1 Antichymotrypsin / AACT antibody

SKU : BHA10800315

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Mfr.No.	FNab00317
Alternative Names	A1Antichymotrypsin ; AACT ; ACT ; Alpha1antichymotrypsin ; GIG24 ; GIG25 ; SerpinA3 ; SERPINA3
Background	The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Categories	Primary Antibodies
Cellular Localization	Secreted
Clonality	polyclonal
Description	Human SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a member of the serine protease inhibitor class, and is a plasma alpha globulin glycoprotein which increases in the blood during the inflammatory process. SerpinA3, is also an inhibitor of neutrophil cathepsin G, mast cell chymases and pancreatic chymotrypsin. SerpinA3 is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease. SerpinA3 has also been implicated in the pathology of a number of devastating human diseases including chronic obstructive pulmonary disease (COPD), Parkinson’s disease (PD), Alzheimer’s disease (AD), Stroke, Cystic Fibrosis, Cerebral Haemorrhage and Multiple System Atrophy.
Host	Rabbit
Immunogen	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	secreted
Synonyms	A1 Antichymotrypsin, AACT, ACT, Alpha 1 antichymotrypsin, GIG24, GIG25, Serpin A3, SERPINA3

Uniprot	P01011
Gene Id	12
Research Area	Cancer, Immunology, Cardiovascular, Metabolism
Weight	48kDa,observed 65kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB

Description

ELISA ; IHC ; WB

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200

Manual	FNab00317.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800315	FNab00317	100ug	$280		Add to Cart

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