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Home / Primary Antibodies / Polyclonal Antibodies

ALKBH7 antibody

SKU : BHA10800313

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Mfr.No.	FNab00315
Alternative Names	ABH7 ; ALKBH7 ; SPATA11 ; UNQ6002
Background	May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).
Categories	Primary Antibodies
Cellular Localization	Mitochondria
Clonality	polyclonal
Description	May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Host	Rabbit
Immunogen	alkB, alkylation repair homolog 7(E. coli)
Isotype	IgG
Molecular Weight	25 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Mitochondrion
Synonyms	ABH7, ALKBH7, SPATA11, UNQ6002

Uniprot	Q9BT30
Gene Id	84266
Research Area	Metabolism
Weight	25kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800313	FNab00315	100ug	$240		Add to Cart

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