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Home / Primary Antibodies

ALK Antibody / Anaplastic Lymphoma Kinase (V7410)

SKU : BHA17116167

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NSJ Bioreagents

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Mfr.No.	V7410, V7410-20UG, V7410-100UG
Clonality	Monoclonal
Description	The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,Â NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Rabbit
Immunogen Region	Recombinant full length human protein was used as the immunogen for this recombinant ALK antibody.
Isotype	IgG,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	Yes
Subcellular Location	Cytoplasmic, nuclear

Uniprot	Q9UM73
Clone No	ALK1/2766R

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein A affinity
Storage	Store the recombinant recombinant ALK antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17116167-1	V7410-20UG	20ug	$219		Add to Cart
BHA17116167-2	V7410-100UG	100ug	$499		Add to Cart

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