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Home / Primary Antibodies / Polyclonal Antibodies

AKTIP antibody

SKU : BHA10800272

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Mfr.No.	FNab00274
Alternative Names	AKTinteractingprotein ; AKTIP ; FT1 ; FTS ; Fusedtoesproteinhomolog
Background	The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Membrane
Clonality	polyclonal
Description	Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.
Host	Rabbit
Immunogen	AKT interacting protein
Isotype	IgG
Molecular Weight	36 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Cytoplasm, Membrane
Synonyms	AKT interacting protein, AKTIP, FT1, FTS, Fused toes protein homolog

Uniprot	Q9H8T0
Gene Id	64400
Research Area	Metabolism
Weight	32kDa,observed 70kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00274.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800272	FNab00274	100ug	$240		Add to Cart

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