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Home / Primary Antibodies / Polyclonal Antibodies

AKT3 antibody

SKU : BHA10800271

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Mfr.No.	FNab00273
Alternative Names	AKT3 ; DKFZp434N0250 ; PKBGAMMA ; PKBG ; PRKBG ; ProteinkinaseAkt3 ; ProteinkinaseBgamma ; RACgamma ; RACPKgamma ; STK2
Background	AKT3 is one of 3 closely related serine/threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Membrane, Nucleus
Clonality	polyclonal
Description	AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
Host	Rabbit
Immunogen	v-akt murine thymoma viral oncogene homolog 3(protein kinase B, gamma)
Isotype	IgG
Molecular Weight	54 kDa
Reactivity	Human, Mouse, Rat, Zebrafish
Regulatory	RUO
Subcellular Location	Cytoplasm, Membrane, Nucleus
Synonyms	AKT3, DKFZp434N0250, PKB GAMMA, PKBG, PRKBG, Protein kinase Akt 3, Protein kinase B gamma, RAC gamma, RAC PK gamma, STK 2

Uniprot	Q9Y243
Gene Id	10000
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Neuroscience
Weight	54kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800271	FNab00273	100ug	$240		Add to Cart

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