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Home / Primary Antibodies / Polyclonal Antibodies

AKR1C3 antibody

SKU : BHA10800260

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Mfr.No.	FNab00262
Alternative Names	17betaHSD5 ; 3alphaHSDtype2 ; 3alphaHSDtypeII ; brain ; AKR1C3 ; DD3 ; DD3 ; DDX ; Dihydrodioldehydrogenase3 ; HA1753 ; HAKRB
Background	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Host	Rabbit
Immunogen	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Isotype	IgG
Molecular Weight	37 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	17 beta HSD 5, 3 alpha HSD type 2, 3 alpha HSD type II, brain, AKR1C3, DD 3, DD3, DDX, Dihydrodiol dehydrogenase 3, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, Indanol dehydrogenase, KIAA0119, PGFS, Prostaglandin F synthase

Uniprot	P42330
Gene Id	8644
Research Area	Metabolism
Weight	37kDa,observed 34kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab00262.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800260	FNab00262	100ug	$240		Add to Cart

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