This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm
Clonality
polyclonal
Description
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Host
Rabbit
Immunogen
aldo-keto reductase family 1, member B1 (aldose reductase)
Isotype
IgG
Molecular Weight
36 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm
Synonyms
AKR1B1, Aldose reductase, AR, ALDR1, ADR
Uniprot
P15121
Gene Id
231
Research Area
Metabolism
Weight
36kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)