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Home / Primary Antibodies / Polyclonal Antibodies

AKAP10 antibody

SKU : BHA10800248

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Mfr.No.	FNab00250
Alternative Names	AKAP10 ; DAKAP2 ; AKAP10 ; PRKA10 ; DAKAP2
Background	Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase(By similarity).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Membrane, Mitochondria
Clonality	polyclonal
Description	Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
Host	Rabbit
Immunogen	A kinase(PRKA) anchor protein 10
Isotype	IgG
Molecular Weight	74 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Membrane, Mitochondrion
Synonyms	AKAP10, D AKAP2, AKAP 10, PRKA10, D AKAP 2

Uniprot	O43572
Gene Id	11216
Research Area	Signal Transduction
Weight	74kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-200

Tested Application

WB: 1:500-1:5000; IHC: 1:20-200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800248	FNab00250	100ug	$260		Add to Cart

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